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                  • EI
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                  中國精品科技期刊2020
                  程曉陽,廖明,何全光,等. 三葉青超微粉對酒精性肝損傷大鼠腸道菌群的調節作用[J]. 食品工業科技,2023,44(18):415?424. doi: 10.13386/j.issn1002-0306.2022090022.
                  引用本文: 程曉陽,廖明,何全光,等. 三葉青超微粉對酒精性肝損傷大鼠腸道菌群的調節作用[J]. 食品工業科技,2023,44(18):415?424. doi: 10.13386/j.issn1002-0306.2022090022.
                  CHENG Xiaoyang, LIAO Ming, HE Quanguang, et al. Effects of Tetrastigma hemsleyanum Superfine Powder on Intestinal Microflora in Rats with Alcohol-Induced Liver Injury[J]. Science and Technology of Food Industry, 2023, 44(18): 415?424. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022090022.
                  Citation: CHENG Xiaoyang, LIAO Ming, HE Quanguang, et al. Effects of Tetrastigma hemsleyanum Superfine Powder on Intestinal Microflora in Rats with Alcohol-Induced Liver Injury[J]. Science and Technology of Food Industry, 2023, 44(18): 415?424. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022090022.

                  三葉青超微粉對酒精性肝損傷大鼠腸道菌群的調節作用

                  Effects of Tetrastigma hemsleyanum Superfine Powder on Intestinal Microflora in Rats with Alcohol-Induced Liver Injury

                  • 摘要: 目的:研究三葉青超微粉能否緩解酒精引起的肝損傷,并探討其保護作用機制,為開發酒精性肝損傷輔助治療產品提供新的研究思路。方法:連續給予大鼠8周酒精制備肝損傷模型,同時給予大鼠灌胃不同劑量的三葉青超微粉,觀察其對酒精性肝損傷的保護作用。檢測大鼠血清中ALT、AST、ALP和肝組織中GSH、SOD、MDA的變化,觀察肝組織病理切片損傷情況,并采集糞便提取基因組DNA,進行16S rDNA 全長測序分析。結果:與模型組比較,三葉青中、高劑量(0.5和1.0 g·kg?1)可顯著降低大鼠ALT、AST和ALP水平及MDA含量(P<0.05),提高SOD和GSH活性,減輕肝組織病變。肝組織切片證實,三葉青超微粉明顯改善酒精所引起的肝細胞腫脹和脂肪變性,治療效果類似于陽性藥聯苯雙酯。腸道菌群分析表明,酒精性肝損傷大鼠腸道菌群結構發生顯著變化;三葉青、陽性藥干預對腸道菌群在門、屬、種水平上較模型組均有一定程度的改善;三葉青能有效恢復因酒精增加的普雷沃菌屬,降低的約氏乳桿菌、毛桿菌豐度,效果優于陽性藥對照組(P<0.05)。結論:首次驗證了三葉青超微粉對大鼠酒精性肝損傷有明顯的保護作用,其機制可能與其抗氧化應激作用及腸道菌群的調節有關。

                     

                    Abstract: Objective: To investigate and reveal protective mechanism which the Tetrastigma hemsleyanum (SYQ) ultramicro powder alleviate alcohol-induced liver injury, and to provide a new research idea for clinical treatment of alcohol-induced liver injury. Methods: The rat model of alcoholic liver injury was established by continuous administration of alcohol for 8 weeks. At the same time, rats were given different doses SYQ ultramicro powder by intragastric to observe its protective effect on liver injury. Changes of ALT, AST, ALP and GSH, SOD, MDA were detected in serum and liver tissue, respectively. Pathological sections of liver tissue were used to observe the damage. Genomic DNA was extracted from feces and analyzed by 16S rDNA full-length sequencing. Results: Compared with the model group, medium and high doses of SYQ (0.5 and 1.0 g·kg?1) significantly (P<0.05) reduced the levels of ALT, AST ALP and MDA, increased the activities of SOD and GSH, and alleviated the liver lesions in rats. The pathological sections revealed that SYQ ultramicro powder dramatically alleviated liver cells swelling and steatosis, and these effectiveness were similar to the group of bifendate. Intestinal microflora analysis showed that the intestinal microflora structure significantly changed in rats with alcoholic liver injury. Compared with the model group, both SYQ and bifendate intervention improved the intestinal flora to a certain extent at phylum, genus and species level. SYQ effectively recovered the abundance of Prevotella, Lactobacillus_johnsonii, Raoultibacter_massiliensis altered by alcohol, and the effect of medium doses of SYQ was better than positive control group (P<0.05). Conclusion: The SYQ superfine powder had a significant protective effect on alcoholic-induced liver injury in rats, the mechanism may be related to its antioxidant stress and intestinal flora regulation.

                     

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